Pharmacokinetic parameters in swine after a single IM administration of EXCEDE FOR SWINE Sterile Suspension 100 mg/mL at 2.27 mg CE/lb (5.0 mg CE/kg) BWTable 2. Informa Markets, a trading division of Informa PLC. In case of accidental skin exposure, wash with soap and water.
Sornsen believes the new, single-dose therapy (Excede) will revolutionize respiratory disease management in growing pigs. Pigs heavier than 88 lb (40 kg) will require more than one injection.Most animals will respond to treatment within three to five days. Injection volumes in excess of 2 mL per injection site may result in violative residues. Isolates from the SRD treatment study were obtained from lung tissue collected from non-treated pigs prior to enrollment and saline-treated pigs that died or were euthanized during the study. At necropsy, half of the injection sites at both 3 and 7 days post-injection were scored as "negative" for irritation and the other half were scored as "slight irritation". Acceptable quality control ranges for ceftiofur against CLSI recommended American Type Culture Collection (ATCC) reference strains At 3, 7 and 10 days post-injection, pairs of animals were euthanized and the neck injection sites were dissected for pathological examination (4 injection sites per time point). Ceftiofur minimum inhibitory concentration (MIC) values* of indicated pathogens isolated from SRD treatment and control field studies conducted in the U.S.** The lowest MIC to encompass 50% and 90% of the most susceptible isolates, respectively.The minimum inhibitory concentrations (MICs) of ceftiofur against indicated SRD pathogens were determined using methods recommended by the Clinical and Laboratory Standards Institute (CLSI) using the M31-A and M31-A3 standards for the SRD treatment (2000-2001) and control (2009) studies, respectively. The injections were well tolerated in all pigs. Therefore, studies conducted with ceftiofur sodium are adequate to evaluate the systemic safety of CCFA. These bacteria are extremely sensitive to ceftiofur, as the chart below shows. Results from a five-day tolerance study in normal feeder pigs indicated that ceftiofur sodium produced no overt adverse signs of toxicity and was well tolerated when administered at 57 mg CE/lb (125 mg/kg) BW (more than 25 times the recommended dosage of CCFA) for five consecutive days. Let us direct you to the resources designed for you Injection volumes in excess of 2 mL per injection site may result in violative residues.● Following label use as a single treatment, a 14-day pre-slaughter withdrawal period is required.The safety of ceftiofur has not been demonstrated for pregnant swine or swine intended for breeding.Administration of EXCEDE FOR SWINE Sterile Suspension 100 mg/mL as directed may induce a transient reaction at the site of injection and underlying tissues that may result in trim loss of edible tissue at slaughter.An injection site tolerance study demonstrated that EXCEDE FOR SWINE Sterile Suspension 100 mg/mL is well tolerated in pigs.
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